Thermo-Regulation Research

Investigator: John P. Handrakis, Pt, DPT, Ed.D

 

In persons with tetraplegia, to maintain a constant body temperature is a challenge, even when exposed to small changes in temperature. Our investigators are studying the responses of the body and their effect on thinking to mild changes in environmental temperature under carefully controlled conditions in a thermal testing room. Drug and non-drug interventions, to assist the body to keep temperature in the normal range, are being tested.


Thermoregulation and Cognition during Cool Ambient Exposure in Tetraplegia

You will be asked to visit the laboratory for 2 visits. Visit 1: Your core temperature, metabolic rate, skin temperature, and biomarkers in your blood in response to cold temperature exposure (40 minutes at 81 °F, and then up to 2 hours at 64 °F) will be assessed. Visit 2: Will be identical to visit 1, except that we will give you one 10 mg tablet of midodrine (a standard blood pressure raising medicine) and your responses to the cold will be measured.

Inclusion Criteria: Chronic SCI at levels C3-T1; no contraindication to midodrine; no acute illness; no high blood pressure; no heart, thyroid, kidney or blood vessel disease; no diabetes

Time Commitment: 2 days, 4 hours each
Reimbursement: $100/day


Effect of Heat Exposure on Cognition in Persons with Tetraplegia

You will be asked to visit the laboratory for 1 visit. During this visit, your core temperature, sweating rate, metabolic rate, skin temperature, and biomarkers in your blood in response to heat exposure (40 minutes at 81 °F, and then up to 2 hours at 95 °F) will be assessed.

Inclusion Criteria: Chronic SCI at levels C3-T4; no acute illness; no high blood pressure; no heart, thyroid, kidney or blood vessel disease; no diabetes

Time Commitment: 1 day, 4 hours
Reimbursement: $100/day


Postprandial Thermogenesis in Persons with SCI

You will be asked to visit the laboratory for 3 visits. During each visit, you will be asked to eat a 600-calorie meal. Then your core temperature, metabolic rate, sweating rate, and skin temperature will be assessed for three hours.

Inclusion Criteria: Chronic SCI at levels C4-T1; no allergies to meal ingredients; no acute illness; no high blood pressure; no heart, thyroid, kidney or blood vessel disease; no diabetes; no stomach ulcers

Time Commitment: 3 days, 4 hours each
Reimbursement: $75/day


Thermal Comfort and its Effects on Routine Daily Activities in Persons with SCI During Seasonal Hot Temperatures

You will be asked to fill out 2 short surveys (2-2.5 pages). One survey assesses how comfortable you feel in the heat, and the other will document the effects of heat on your usual daily activities.

Inclusion Criteria: Chronic SCI at levels C3-T12; no acute illness; no high blood pressure; no heart, thyroid, kidney or blood vessel disease

Time Commitment: 5 minutes/survey
Reimbursement: none


Thermal Comfort and its Effects on Routine Daily Activities in Persons with SCI

You will be asked to fill out 2 short surveys (2-2.5 pages). One survey assesses how comfortable you feel in the cold, and the other will document the effects of cold on your usual daily activities.

Inclusion Criteria: Chronic SCI at levels C3-T12; no acute illness; no high blood pressure; no heart, thyroid, kidney or blood vessel disease

Time Commitment: 5 minutes/survey
Reimbursement: none



ALSO RECRUITING AT KESSLER INSTITUTE OF REHABILITATION:
Christopher M. Cirnigliaro, M.S.,CES,CBDT
Senior Research Coordinator
Kessler Institute for Rehabilitation
1199 Pleasant Valley Way
West Orange, NJ 07052
Tel: (973) 731-3900 x2755
Fax: (973) 243-6892

Studies Underway

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Contact Us

 

Tishina Tittley, BA
Research Coordinator
(718) 584-9000 x2197
Tishina.tittley@va.gov

Jessica Bart, SPT
Research Assistant
(718) 584-9000 x2197

Christian Barton, SPT
Research Assistant
(718) 584-9000 x219
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ALSO RECRUITING AT KESSLER INSTITUTE OF REHABILITATION:
Christopher M. Cirnigliaro, M.S.,CES,CBDT
Senior Research Coordinator
Kessler Institute for Rehabilitation
1199 Pleasant Valley Way
West Orange, NJ 07052
Tel: (973) 731-3900 x2755
Fax: (973) 243-6892